Molecular Formula | C9H8ClNO3 |
Molar Mass | 213.62 |
Density | 1.566 |
Melting Point | 242 °C(dec.) |
Boling Point | 406.5±45.0 °C(Predicted) |
Solubility | DMSO (Slightly), Methanol (Slightly, Heated) |
Appearance | Solid |
Color | Light Brown |
pKa | 4.45±0.20(Predicted) |
Storage Condition | 2-8°C(protect from light) |
Application | 4-amino-5-chloro-2, 3-dihydrobenzofuran-7-carboxylic acid is a carboxylic acid derivative, which can be used as a pharmaceutical intermediate. |
preparation | . The method is to first add 4-(acetylamino) -2-hydroxy-3-(2-hydroxyethyl) benzoate methyl ester to an organic solvent, add triphenylphosphine and diethyl azodicarboxylate to close the ring to obtain 4-acetylamino -2, 3-dihydrobenzofuran-7-methyl acetate crude product, the crude product 4-acetamido-5-chloro-7-benzofuran-formate was directly chlorinated with N-chlorinated succinimide to obtain the crude product 4-acetamido-5-chloro-2-dihydrobenzofuran-7-carboxylic acid by hydrolysis and purification to obtain the pure product 4-amino-5-chloro-2, 3-dihydrobenzofuran-7-carboxylic acid. |